Advances in near infrared photoimmunotherapy of tumor
10.11665/j.issn.1000-5048.20200604
- VernacularTitle:肿瘤的近红外光免疫治疗研究进展
- Author:
Fang LI
1
;
Junbo XIN
;
Qin SHI
;
Chengqiong MAO
Author Information
1. 江苏医药职业学院药学院
- Publication Type:Journal Article
- Keywords:
near infrared photoimmunotherapy;
tumor;
targeted photodynamic therapy;
advances
- From:
Journal of China Pharmaceutical University
2020;51(6):664-674
- CountryChina
- Language:Chinese
-
Abstract:
Near infrared photoimmunotherapy (NIR-PIT) is a highly selective molecularly targeted phototherapy for cancer which is based on injecting a conjugate of IRDye700DX,a water-soluble near-infrared silicon-phthalocyanine dye,and a monoclonal antibody that targets an antigen on the cancer cell surface. Subsequent local irradiation of NIR light causes the rapid and specific tumor cell death. Due to the good clinical translation prospects of NIR-PIT,this paper summarizes the influencing factors,antitumor mechanism,main challenges and recent strategies,which may benefit for its research and clinical application.
