Research progress of the resistance mechanism and reversal strategies of ALK inhibitors in NSCLC
10.11665/j.issn.1000-5048.20200603
- VernacularTitle:ALK抑制剂在NSCLC中的耐药机制及逆转策略的研究进展
- Author:
Di ZHANG
1
;
Dongzhi RAN
;
Yu YU
;
Zongjie GAN
Author Information
1. 重庆医科大学药学院
- Publication Type:Journal Article
- Keywords:
NSCLC;
ALK inhibitors;
drug resistance;
reversal strategies;
advances
- From:
Journal of China Pharmaceutical University
2020;51(6):655-663
- CountryChina
- Language:Chinese
-
Abstract:
Anaplastic lymphoma kinase (ALK) inhibitors are regarded as effective drugs for the treatment of ALK-positive NSCLC. However,the emergence of drug resistance has limited its further clinical application. This article briefly introduces the resistance mechanism of ALK inhibitors including acquired secondary mutations,gene amplification,bypass signaling pathway activation and reviews the recent advances on the reversal strategies such as drug combination,developing novel PROTACs to overcome drug resistance,so as to provide some reference for the development of ALK inhibitors.
