Advances of long noncoding RNAs in myocardial fibrosis
10.11665/j.issn.1000-5048.20200602
- VernacularTitle:长链非编码RNAs在心肌纤维化中的研究进展
- Author:
Xiaoshi LI
1
;
Xunxun WU
;
Zuguo ZHENG
;
Hua YANG
;
Ping LI
Author Information
1. 中国药科大学天然药物活性组分与药效国家重点实验室
- Publication Type:Journal Article
- Keywords:
lncRNAs;
myocardial fibrosis;
gene expression regulation;
biomarker;
therapeutic target
- From:
Journal of China Pharmaceutical University
2020;51(6):646-654
- CountryChina
- Language:Chinese
-
Abstract:
Accumulating studies have recently shown that long noncoding RNAs (lncRNAs) are involved in the initiation and progression of myocardial fibrosis,a common histological characteristic of heart conditions and prominent global health issues. LncRNAs are prominently served as regulatory molecules via interaction with DNA,RNA and proteins in transcriptional and post-transcriptional processes. They can change morphological structure and biochemical metabolism of cardiac cells and regulate homeostasis of the cardiac extracellular matrix. Therefore,lncRNAs show great potential as diagnostic and prognostic biomarkers and therapeutic targets for anti-fibrotic treatment.
