A Case of Leopard Syndrome with Atypical Psychosis.
- Author:
Dong Gee LEE
1
;
Jeong Gee KIM
Author Information
1. Department of Neuropsychiatry, Maryknoll Hospital, Busan, Korea.
- Publication Type:Case Report
- Keywords:
Leopard Syndrome;
lentigine;
Autism
- MeSH:
Autistic Disorder;
Buttocks;
Cafe-au-Lait Spots;
Deafness;
Electrocardiography;
Flatfoot;
Genitalia;
Humans;
Hypertelorism;
Intellectual Disability;
Joints;
Lentigo;
LEOPARD Syndrome*;
Neural Plate;
Neurocutaneous Syndromes;
Panthera*;
Psychotic Disorders*;
Pulmonary Valve Stenosis;
Skin
- From:Journal of Korean Neuropsychiatric Association
2002;41(3):563-570
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Leopard syndrome is a neurocutaneous syndrome which may affect a variety of organ systems in the embryological aspects. It presents lentigines, EKG abnormalities, ocular hypertelorism, pulmonary stenosis, abnormalities of genitalia, retardation of growth, and deafness as major teatures.We report a case of Leopard Syndrome with atypical psychotic features. The patient had many lentigenies on the face, cafe au lait spots on the part of the waist and the buttocks, mild atrial regugitation, clinodactyly, hyperextensibility of distal interphalangeal joint, flat foots, subclinical hypothyrodism, sensorineural deafness, and mild mental retardation. He also had autistic disorder, compulsion, pathologic collection, and violent behaviors as psychiatric problems. This raises a possibility that psychiatric diseases may be related to the variation of neuroectoderm. In clinical practice, when psychopathic patients with specific skin lesions are seen for consultation, the consideration of embryologically common aspects of both disease groups can be helpful to the discovery of abnormalities in other organs and to its treatment.
