Mean Platelet Component to Measure Platelet Activation in Ischemic Stroke: Preliminary Study.
- Author:
Don Soo KIM
1
;
Seung Hwa RYU
;
Jong Wook LEE
;
Yong Duk KIM
;
Young Chul CHOI
Author Information
1. Department of Neurology, Konyang University Hospital, Korea. ycchoi@yumc.yonsei.ac.kr
- Publication Type:Original Article
- Keywords:
Mean platelet component(MPC);
Stroke;
Platelet activation
- MeSH:
Alzheimer Disease;
Blood Platelets*;
Cerebral Infarction;
Coronary Artery Disease;
Hematology;
Humans;
Myeloproliferative Disorders;
Platelet Activation*;
Pre-Eclampsia;
Stroke*
- From:Journal of the Korean Neurological Association
2002;20(3):223-226
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Abnormal platelet activation has been identified in several disorders characterizedby vascular patholo-gy including coronary artery disease, Alzheimer disease, myeloproliferative disorders, diabetes, preeclampsia, inflam-matory bowel disease and glomerular disease. Antiplatelet therapy has been valuable in the management of some of these conditions. The aim of this study is to verify usefulness of mean platelet component (MPC) concentration as a marker of thrombotic process in patients with cerebral infarction. Our hypothesis is that MPC as measured by the ADVIA(R) 120 hematology system is used to detect and monitor platelet activation associated with thrombotic process of ischemic stroke. METHODS: To study the existence of platelet activation at the onset of cerebral infarction, mean platelet concentration of platelets were measured daily during post-stroke 10 days. Thirty-four acute thrombotic cerebral infarction and seventeen age-matched healthy persons were selected for this study. To investigate the time course of the platelet MPC changes observed in stroke patients, the blood samplings for MPC measuring were done and analyzed on the ADVIA 120(R) system. RESULTS: There was a statistically significant decrease in MPC concentration of the platelets at post-stroke 3rd to 7th day compared to the control group ( p < 0.05). CONCLUSIONS: We conclude that a reduction of MPC as measured by the ADVIA 120(R) hematology system may be used to detect and monitor thrombotic process associated with platelet activation in ischemic stroke.
