Anticancer Effects of Zaoxiu Compound Decoction on H22 Mice with Heps
10.3969/j.issn.1674-6348.2013.02.008
- Author:
Yan-qing JIANG
1
Author Information
1. Tianmu College of Zhejiang A and F University
- Publication Type:Journal Article
- Keywords:
Anticancer;
H22 mouse;
Heps;
Pathological observation;
Zaoxiu Compound Decoction
- From:
Chinese Herbal Medicines
2014;5(2):125-128
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the anticancer effects of the Zaoxiu Compound Decoction (ZCD) on H22 mice with Heps and the influence on the construction of H22 cells. Methods: With in vivo techniques, the antineoplastic drugs were given to hepatoma H22 model mice which were randomly divided into negative control (physiological saline), positive control (cyclophosphamide), high- and low-dose ZCD groups. After 10-d administration, the pathological examinations of tumor tissue, livers, and kidneys in mice were carried out and the inhibitory rate on tumor was calculated. Results: The high- and low-dose ZCD had obvious inhibition on H22 cells. The pathological observation showed that high- and low-dose ZCD had a strong inhibitory effect on H22 cells as well as positive control, with few toxic effects to the livers and kidneys in mice. Conclusion: ZCD has the anticancer effect and has no obvious toxic effects on the model mice. © 2013 Tianjin Press of Chinese Herbal Medicines.
