A Novel Bihomoflavanonol with an Unprecedented Skeleton from Pteridium aquilinum
10.3969/j.issn.1674-6348.2013.02.002
- Author:
Nai-dong CHEN
1
Author Information
1. College of Biotechnology and Pharmaceutical Engineering
- Publication Type:Journal Article
- Keywords:
Antitumor activity;
Bihomoflavononol;
Pteridaceae;
Pteridium aquilinum;
Pteridium III
- From:
Chinese Herbal Medicines
2014;5(2):96-100
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To seek the flavonoids with the unique structure and to investigate the chemical ingredients in the flavonoid-rich plant- Pteridium aquilinum. Methods: The 80% EthOH extract from the degreased powder of P. aquilinum was partitioned by petroleum ether, CHCl3, EtOAc, n-butanol, and water, respectively. The EtOAc fraction was sequentially subjected to silica gel column, repeated Sephadex LH-20 column, and preparative TLC to give a new compound. The antitumor activity of the novel flavonoid was primarily evaluated by MTT. Results: Compound 1, a biflavonoid with the unique structure named as pteridium III with an unprecedented bihomoflavanonol skeleton, was isolated from P. aquilinum. Compound 1 showed the in vitro antitumor activity against lung cancer cell NCI-H46, melanoma cell A375, and glioma cell U-7MG corresponding to the IC50 values of 22.9, 106.7, and 1540.5 μmol/L, respectively. No inhibition on gastric carcinoma SGC-7901 and prostatic carcinoma PC-3 was observed in the experiment. Conclusion: A rare bihomoflavononol derivative, pteridium III, is obtained from the plant, which could enrich our knowedge on the chemical structures of flavonoids and bioactive constituents in P. aquilinum. © 2013 Tianjin Press of Chinese Herbal Medicines.
