Optimization for preparation of lemon-catalyzed ginsenoside Rg3 by response surface method
10.3969/j.issn.1674-6348.2013.03.007
- Author:
Cheng-peng SUN
1
Author Information
1. Department of Chemistry
- Publication Type:Journal Article
- Keywords:
Conversion;
Ginsenoside Rg3;
Lemon;
Protopanaxadiol type saponins;
Response surface method
- From:
Chinese Herbal Medicines
2014;5(3):217-223
- CountryChina
- Language:Chinese
-
Abstract:
Objective: Ginsenoside Rg3 was prepared by converting protopanaxadiol (PPD)-type saponins using lemon juice as the catalyst. Methods: Preparation of ginsenoside Rg3 was optimized by response surface method (RSM) based on a four-factor and five-level central composite design. Results: The optimal yield of ginsenoside Rg3 was predicted to be 75.98% in the combination of the factors (PPD-type saponins concentration of 23.6 mg/mL, lemon juice concentration of 97.6% at 85.7 °C for 130.0 min) through the canonical analysis and ridge analysis with maximum responses. Under the optimum conditions, the actual yield of ginsenoside Rg3 was 75.57%. Conclusion: RSM is effective to optimize the preparation of ginsenoside Rg3 by lemon-catalyzed PPD-type saponins. The achievement for the preparation of ginsenoside Rg3 would promote the development of health-care production. © 2013 Tianjin Press of Chinese Herbal Medicines.
