Chemical Constituents with Antihyperlipidemic Activities from Desmodium triquetrum
10.1016/S1674-6384(14)60049-6
- Author:
Jia-ni WU
1
Author Information
1. Research Center on Life Sciences and Environmental Sciences, Harbin University of Commerce
- Publication Type:Journal Article
- Keywords:
6'-O-cis-p-coumaroyl-3,5-dihydroxyphenyl-β-D-gluco-pyranoside;
6-O-(E)-p-hydroxy-cinnamoyl-α-glucose;
6-O-(E)-p-hydroxy-cinnamoyl-β-glucose;
Antihyperlipidemic activities;
Desmodium triquetrum
- From:
Chinese Herbal Medicines
2014;6(4):324-327
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the chemical constituents from Desmodium triquetrum and their antihyperlipidemic activities. Methods: The constituents of D. triquetrum were isolated and purified using various column chromatographies. Their chemical structures were elucidated using extensive spectroscopic methods. The lipid-lowering effects of the isolates were evaluated in HepG2 cells. Results: Nine compounds were obtained from the ethanol extract of D. triquetrum and determined to be 6'-. O-cis-p-coumaroyl-3,5-dihydroxyphenyl-β-. D-glucopyranoside (1), tadehaginoside (2), rutin (3), quercetin-3-O-β-. D-glucopyranoside (4), quercetin-3-O-β-. D-galactopyranoside (5), 6-. O-(E)-. p-hydroxy-cinnamoyl-β-glucose (6), 6-. O-(E)-. p-hydroxy-cinnamoyl-α-glucose (7), kaempferol-3-O-β-. D-rutinoside (8), and 3-. O-β-D-galacopyranosyl (6-1)-α-. L-rhamnosyl quercetin (9). Compounds 1 and 2 significantly reduced the intracellular content of total cholesterols and triglycerides. Conclusion: Compound 1 is a new phenolic compound and exhibits potent anti-hyperlipidemic activity. Additionally, compounds 6 and 7 are isolated from D. triquetrum for the first time.
