Diacylglycerol Compounds from Barks of Betula platyphylla with Inhibitory Activity against Acyltransferase
10.1016/S1674-6384(14)60026-5
- Author:
Nan ZHANG
1
Author Information
1. College of Pharmacy, Beihua University
- Publication Type:Journal Article
- Keywords:
Betucaseae;
Betula platyphylla;
Diacylglycerol acyltransferase1;
Lupane triterpenes
- From:
Chinese Herbal Medicines
2015;6(2):164-167
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To identify the active compounds from the barks of Betula platyphylla for inhibitory on diacylglycerol acyltransferase (DGAT1). Methods: Bioassay-guided fractionation resulted in the isolation of DGAT1 inhibitory activity of lupane triterpenes. Results: Ten compounds were identified as lupenone (1), lupeol (2), betulinic acid (3), betulinaldehyde (4), betulin (5), 3-deoxybetulonic acid (6), glochidonol (7), lup-20/29-ene-1β/3β-diol (8), 3α-hydroxy-lup-20(29)-en-23,28-dioic acid (9), and 3α,11α-dihydroxy-23-oxo-lup-20(29)-en-28-oic acid (10). Compounds 3-6, 9, and 10 inhibited DGAT1 with IC50 values ranging from (11.2 ± 0.3) to (38.6 ± 1.2) μmol/L. Conclusion: Compounds 6, 9, and 10 are first isolated from the barks of B. platyphylla., and compounds 3-6, 9, and 10 from the barks of B. platyphylla are responsible for the inhibition on DGAT1. © 2014 Tianjin Press of Chinese Herbal Medicines.
