Cardiovascular risk factors of early atherosclerosis in school-aged children after Kawasaki disease.
10.3345/kjp.2014.57.5.217
- Author:
Hyun Jeong CHO
1
;
Soo In YANG
;
Kyung Hee KIM
;
Jee Na KIM
;
Hong Ryang KIL
Author Information
1. Department of Pediatrics, Chungnam National University School of Medicine, Daejeon, Korea. gilhongr@gmail.com
- Publication Type:Original Article
- Keywords:
Risk factors of cardiovascular diseases;
Atherosclerosis;
Mucocutaneous lymph node syndrome
- MeSH:
Apolipoproteins;
Atherosclerosis*;
Biomarkers;
Blood Pressure;
Brachial Artery;
C-Reactive Protein;
Child*;
Cholesterol;
Homocysteine;
Humans;
Lipoproteins;
Mucocutaneous Lymph Node Syndrome*;
Pulse Wave Analysis;
Risk Factors*;
Triglycerides;
Vascular Stiffness
- From:Korean Journal of Pediatrics
2014;57(5):217-221
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: The aim of this study was to determine whether school-aged children with Kawasaki disease (KD) have an increased risk for early atherosclerosis. METHODS: The study included 98 children. The children were divided into the following groups: group A (n=19), KD with coronary arterial lesions that persisted or regressed; group B (n=49), KD without coronary arterial lesions; and group C (n=30), healthy children. Anthropometric variables and the levels of biochemical markers, including total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), apolipoprotein A, apolipoprotein B, homocysteine, high-sensitivity C-reactive protein (hs-CRP), and brachial artery stiffness using pulse wave velocity were compared among the three groups. RESULTS: There were no significant differences in blood pressure and body index among the three groups. Additionally, there was no sex-specific difference. Moreover, the levels of triglyceride, HDL-C, apolipoprotein A, and hs-CRP did not differ among the three groups. However, the levels of total cholesterol (P=0.018), LDL-C (P=0.0003), and apolipoprotein B (P=0.029) were significantly higher in group A than in group C. Further, the level of homocysteine and the aortic pulse wave velocity were significantly higher in groups A and B than in group C (P=0.0001). CONCLUSION: School-aged children after KD have high lipid profiles and arterial stiffness indicating an increased risk for early atherosclerosis.
