Kikuchi-Fujimoto disease mimicking malignant lymphoma with 2-18Ffluoro-2-deoxy-D-glucose PET/CT in children.
10.3345/kjp.2014.57.5.226
- Author:
Ji Eun KIM
1
;
Eun Kyung LEE
;
Jae Min LEE
;
Soon Hwan BAE
;
Kwang Hae CHOI
;
Young Hwan LEE
;
Jeong Ok HAH
;
Joon Hyuk CHOI
;
Eun Jung KONG
;
Ihn Ho CHO
Author Information
1. Department of Pediatrics, Yeungnam University College of Medicine, Daegu, Korea. johah@med.yu.ac.kr
- Publication Type:Original Article
- Keywords:
Kikuchi-Fujimoto disease;
Lymphoma;
Positron emission tomography
- MeSH:
Academic Medical Centers;
Bone Marrow;
Child*;
Diagnosis;
Electrons;
Fever;
Fluorodeoxyglucose F18;
Histiocytic Necrotizing Lymphadenitis*;
Humans;
Kidney;
Lymphatic Diseases;
Lymphoma*;
Medical Records;
Orbit;
Pediatrics;
Pleura;
Positron-Emission Tomography;
Positron-Emission Tomography and Computed Tomography*;
Retrospective Studies;
Thymus Gland
- From:Korean Journal of Pediatrics
2014;57(5):226-231
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: Kikuchi-Fujimoto disease (KFD) is a benign disease, which is characterized by a cervical lymphadenopathy with fever, and it often mimics malignant lymphoma (ML). 2-[18F]fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography (18F-FDG PET/CT) is a powerful imaging modality for the diagnosis, staging and monitoring of ML, with the limitations including the nonspecific FDG uptake in infectious or inflammatory processes. This study compared clinical manifestations and PET/CT findings between KFD and ML patients. METHODS: We retrospectively reviewed the medical records of 23 patients with KFD and 33 patients with ML, diagnosed histopathologically, between January 2000 and May 2013 at the Department of Pediatrics, Yeungnam University Medical Center. Among them, we analyzed the clinical manifestations, laboratory findings and characteristics, and the amount of 18F-FDG uptake between 8 KFD and 9 ML patients who had 18F-FDG PET/CT. RESULTS: The 18F-FDG PET/CT maximum standardized uptake values (SUVmax) ranged from 8.3 to 22.5 (mean, 12.0) in KFDs, and from 5.8 to 34.3 (mean, 15.9) in MLs. There were no significant differences in SUVmax between KFDs and MLs. 18F-FDG PET/CT with ML patients showed hot uptakes in the extranodal organs, such as bone marrow, small bowel, thymus, kidney, orbit and pleura. However, none of the KFD cases showed extranodal uptake (P<0.001). 18F-FDG PET/CT findings of KFD with nodal involvement only were indistinguishable from those of ML. CONCLUSION: Patients who had extranodal involvement on PET/CT were more likely to have malignancy than KFD.
