Effect of cinnamaldehyde on 1, 3-β-D-glucans in cell wall of Candida albicans in immunosuppressed BALB/c mice
10.1016/j.chmed.2018.08.002
- Author:
Jie-hua DENG
1
Author Information
1. Department of Dermatology, Second Hospital of Hebei Medical University
- Publication Type:Journal Article
- Keywords:
1,3-β-D-glucans;
Candida albicans;
cinnamaldehyde;
fungal cell wall;
invasive pulmonary infection;
targeted drug
- From:
Chinese Herbal Medicines
2018;10(4):445-450
- CountryChina
- Language:Chinese
-
Abstract:
Objective: Invasive pulmonary candidiasis is a disease with high incidence, difficult treatment, poor prognosis, and high mortality. The present study analyzed the influence of cinnamaldehyde on 1,3-β-D-glucans in the cell wall of Candida albicans in order to provide a theoretical basis for the research of antifungal drugs. Methods: An immunosuppressed BALB/c mouse model with invasive pulmonary candidiasis was established by nasal perfusion of 50 µL of C. albicans suspension (107 cfu/mL). 1,3-β-D-glucans examination and electron microscopy were carried out. Fluconazole was used as the control. Results: Cinnamaldehyde was administered at a dose of 240 mg/kg/d for 14 consecutive days, and the measured value of 1,3-β-D-glucans was (1160.62 ± 89.65) pg/mL, whereas that of fluconazole was (4285.87 ± 215.62) pg/mL. The difference between the two groups was statistically significant (P < 0.05). Electron microscopy observation indicated that the 2−3 layers outside the cell wall of C. albicans (1,3-β-D-glucans layer) were rough, deformed, and incomplete, although the cell membrane was clear and intact. Conclusion: Cinnamaldehyde demonstrated special efficacy on 1,3-β-D-glucans in the cell wall of C. albicans.
