Role of semi-purified andrographolide from Andrographis paniculata extract as nano-phytovesicular carrier for enhancing oral absorption and hypoglycemic activity
10.1016/j.chmed.2019.12.004
- Author:
Vinod Kumar VERMA
1
Author Information
1. Department of Pharmaceutical Sciences, Dibrugarh University
- Publication Type:Journal Article
- Keywords:
Andrographis paniculata (Burm. f.) Nees;
andrographolide;
hypoglycemic activity;
liquid dispersion;
nano-phyto vesicle;
soya phosphatidylcholine
- From:
Chinese Herbal Medicines
2020;12(2):142-155
- CountryChina
- Language:Chinese
-
Abstract:
Objective: Andrographis paniculata is a well-known medicinal plant in Southeast Asia, India and China. The plant contains andrographolide (AN), a very important phytochemical used in various health problems. However, AN is low in oral absorption bioavailability of AN due to the rapid clearance and high protein binding capacity. Methods: The present study was aimed to develop a nano-phytovesicular formulation of semi-purified AN extracts from a naturally occurring phospholipid (soya phosphatidylcholine) in order to increase the oral absorption and antihyperglycemic activity in rats. Results: The nano-phyto vesicle of semi-purified AN extracts equivalent to 25 mg /kg AN significantly protected the hyperglycemic condition of rats. The in vitro and in vivo experiments results proved that the nano- phytovesicular system of plant extracts containing AN produced better oral absorption, bioavailability and improved antihyperglycemic activity compared with that of free AN at dose of 50 mg/kg. Conclusion: Hence, the prepared semi-purified extract nano-phytovesicular system is helpful in solving the problem of rapid clearance of AN.
