Brusatol: A potential anti-tumor quassinoid from Brucea javanica
10.1016/j.chmed.2020.05.007
- Author:
Xiao-qi YU
1
Author Information
1. Liaoning Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University
- Publication Type:Journal Article
- Keywords:
antitumor;
Brucea javanica (L.) Merr.;
brusatol;
triterpene lactone
- From:
Chinese Herbal Medicines
2020;12(4):359-366
- CountryChina
- Language:Chinese
-
Abstract:
Brusatol, a triterpene lactone compound mainly from Brucea javanica, sensitizes a broad spectrum of cancer cells. It is known as a specific inhibitor of nuclear factor-erythroid 2-related factor 2 (Nrf2) pathway. In this review, we provide a comprehensive overview on the antitumor effect and molecular mechanisms of brusatol in vitro and in vivo. This review also covers pharmacokinetics studies, modification of dosages forms of brusatol. Increasing evidences have validated the value of brusatol as a chemotherapeutic agent in cancers, which may contribute to drug development and clinical application.
