Expressions of HIF-1α and HSP70 in placenta tissue of patients with pregnancy-induced hypertension syndrome and their significances
10.13481/j.1671-587x.20180225
- Author:
Yonghong LAN
1
Author Information
1. Morphological Laboratory, Hainan Medical College
- Publication Type:Journal Article
- Keywords:
Correlation analysis;
Heat shock protein 70;
Hypoxia-inducible factor-la;
Placenta tissue;
Pregnancy-induced hypertension syndrome
- From:
Journal of Jilin University(Medicine Edition)
2018;44(2):346-349
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the expressions of hypoxia-inducible factor-la (HIF-la) and heat shock protein 70 (HSP70) in the placenta tissue of the patients with pregnancy-induced hypertension syndrome (PIH), and to elucidate the clinical significances of their expressions in the placenta tissue of the patients with PIH. Methods: Twenty-two cases of placenta tissue of the PIH patients (PIH group) and eighteen cases of placenta tissue of the normal pregnant women (control group) were selected. The expressions of HIF-la and HSP70 were detected by immunohistochemical method. The differences of potive expressions rates of HIF-la and HSP70 in placenta tissue of the PIH patients and the normal pregnant women and their relationships in placenta tissue of the PIH patients were analyzed. Results: The positive expression rate of HIF-1α in placenta tissue of the patients in PIH group (81.8%) was higher than that of the normal pregnant women in control group (38.9%) (χ2=7.785, P= 0.005), and the positive expression rate of HSP70 in placenta tissue of the patients in PIH group 90.9%) was higher than that of the normal pregnant women in control group 55.6%) (χ2=6.599, P=0.010). Eighteen cases of placenta tissue with HIF-la positive expression in the PIH patients had HSP70 positive expression (100.0%); among four cases of placenta tissue with HIF-la negative expression, two cases had HSP70 negative expression 50.0%); their expressions in placenta tissue of the PIH patients had positive correlation (r=0.671, P=0.001). Conclusion: The expressions of HIF-la and HSP70 in placenta tissue of the PIH patients are higher, and they have positive correlation.
