Evaluation on efficacy of Huaiqihuang granules in treatment of children with asthma at non-acute attack stage
10.13481/j.1671-587x.20180326
- Author:
Fei ZOU
1
Author Information
1. Department of Pediatrics, First Hospital, Jilin University
- Publication Type:Journal Article
- Keywords:
Asthma;
Children;
Huaiqihuang Granules;
Immunoregulation;
Traditional Chinese medicine syndrome
- From:
Journal of Jilin University(Medicine Edition)
2018;44(3):597-603
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the efficacy of Huaiqihuang Granules in the treatment of the children with asthma at non-acute attack stage and its effect on the immune function indexes of body. Methods: A total of 180 children with asthma at non-acute attack stage were divided into Huaiqihuang Granules treatment group (n=92, treated with traditional Chinese medicine Huaiqihuang Granules along with oral montelukast and inhaled corticosteroid, ICS+MK+H group) and routine treatment group (n=88, only given oral montelukast and inhaled corticosteroid, ICS+MK group). The indexes of asthma attack degrees, traditional Chinese medicine (TCM) syndrome indexes, blood immune function indexes and pulmonary function indexes of the children in two groups were detected. Results: There was no difference in the disease degrees of the children between two groups before treatment (P>0. 05). Compared with routine treatment group, the score of acute attack of asthma of the children in Huaihuang Granules treatment group was decreased after treatment (P<0. 05). Compared with routine treatment group, the scores of dry / loose stools, low-grade fever, cough/expectoration, spiritlessness/anorexia and white tongue fur of the children in Huaiqihuang Granules treatment group were significantly decreased (P< 0. 01), and the scores of perspire during sleep and dry mouth with desire for drinking were decreased (P<0. 05). Compared with routine treatment group, the levels of immunoglobulins (serum IgA, lgG and lgM) of the children in Huaiqihuang Granules treatment group were increased after treatment (P<0. 05) Compared with routine treatment group, the percentages of T cells, Th cells and NK cells of the children in Huaiqihuang Granules treatment group were increased (P<0. 05), the percentage of B cells was decreased (P<0. 05), and there was no difference in the percentages of serum Ts cells of the children between two groups (P>0. 05). Compared with routine treatment group, the peak expiratory flow (PEF) and the ratio value of forced expiratory volume in the first second /forced vital capacity (FEV1/FVC) of the children in Huaiqihuang Granules treatment group were increased (P<0. 05), but there was no difference in FEV1 of the children between two groups (P>0. 05). Conclusion: On the basis of routine treatment, Huaiqihuang Granules can reduce the condition of children with asthma at non-acute attack stage and improve the TCM syndrome and immune function.
