Expressions of IL-17E, IL-17F and their receptors in colorectal carcinoma tissue and their significances
10.13481/j.1671-587x.20180322
- Author:
Xueliang YANG
1
Author Information
1. Department of General Surgery, Affiliated Hospital, Beihua University
- Publication Type:Journal Article
- Keywords:
Colonrectal neoplasms;
Interieukin-17E;
Interleukin-17F;
Interleukin-17RB;
Interleukin-17RC
- From:
Journal of Jilin University(Medicine Edition)
2018;44(3):574-578
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the expressions of interleukin-17E (IL-17E), interleukin-17F (IL-17F) and their receptors interleukin -17RB (IL-17RB), interleukin -17RC (IL-17RC) in enteritis, intestinal polyps and colorectal carcinoma tissues, and to analyze their relationships with the malignancy of colorectal carcinoma. Methods: Immunohistochemistry staining was used to detect the expressions of IL-17E, IL-17RB, IL-17F, and IL-17RC in the tissues of enteritis (n=15), intestinal polyps (n=5) and colorectal carcinoma (n=30). The relationships between IL-17E and IL-17RB, IL-17F and IL-17RC, and the relationships between IL-17E, IL-17F and malignancy of colorectal carcinoma were analyzed. Results: IL-17E, IL-17F, IL-17RB and IL-17RC mainly expressed in glandular epithelial cells, mononuclear cells and vascular endothelial cells as well as partial carcinoma cells. The positive expression rates of IL-17E in enteritis and intestinal polyps tissues were higher than that in colorectal carcinoma tissue (P<0. 05). Compared with enteritis tissue, the positive expression rates of IL-17F in intestinal polyps and colorectal carcinoma tissues were increased (P < 0. 05), which was increased with the increasing of malignancy of coloretal carcinoma. Compared with colorectal carcinoma tissue, the positive expression rates of IL-17RB in enteritis and intestinal polyps tissues were increased (P
