Value of combined detection of tumor markers SCC-Ag, CEA, CYFRA21-1 and D-dimer in early diagnosis of non-small cell lung cancer
10.13481/j.1671-587x.20180524
- Author:
Hongshuai SUN
1
Author Information
1. Department of Clinical Laboratory, Jilin Provincial Tumor Hospital
- Publication Type:Journal Article
- Keywords:
Carcioma;
D dimer;
Non small cell lung;
Receiver operatating characteristic curve;
Tumor markers
- From:
Journal of Jilin University(Medicine Edition)
2018;44(5):1020-1024
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the expression levels of tumor markers squamous cell carcinoma antigen (SCC-Ag), carcinoembryonic antigen (CEA), cytokeratin 19 fragment (CYFRA21-1) and D-dimer (D-D) of the patients with non-small cell lung cancer (NSCLC), and to elucidate its clinical value in the early diagnosis of NSCLC. Methods: A total of 200 patients with NSCLC (NSCLC group), 198 patients with benign lung disease (benign lung disease group) and 196 healthy subjects (control group) were selected and the levels of tumor markers and D-D were detected and compared between groups. The receiver operator characteristic curve (ROC) was drawn to analyze the diagnostic values of different tumor markers, D-D, and joint indicators in the patients with NSCLC. Results: The levels of tumor markers and D-D of the patients in NSCLC group were significantly higher than those in benign lung disease group and control group (P<0. 01). The level of CEA in lung adenocarcinoma was higher than that in lung squamous cell carcinoma (P=0. 005). The levels of SCC-Ag and CYFRA21-1 in lung squamous cell carcinoma were higher than those in lung adenocarcinoma (P=0. 008, P= 0. 004). The levels of tumor markers CKA. CYFRA21-1 and D-D of the patients with stage IE and IV NSCLC were significantly higher than those of the patients with stage I and II NSCLC (P<0. 05). The ROC curves showed that area under curve (AUC) of SCC-Ag was higher than other single indexes (AUC = 0.805); the sensitivity and specificity were 85.42% and 64.21%, respectively. The diagnostic efficacy of the joint indicators was better than that of each single index (AUC = 0.933); the sensitivity and specificity were 86.46% and 88.42%, respectively. Conclusion; Combined detection of tumor markers SCC-Ag, CEA, CYFRA21-1 and D-D can significantly increase the sensitivity and specificity of early diagnosis of NSCLC and has important significance in the early diagnosis of NSCLC.
