Expression of activator of basal transcription 1 in gastric cancer tissue and its clinical significance
10.13481/j-1671-587x.20190118
- Author:
Tianchi MU
1
Author Information
1. Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Jinzhou Medical University
- Publication Type:Journal Article
- Keywords:
Abt1;
Immunohistochemistry;
Stomach neoplasms;
Tissue microarray
- From:
Journal of Jilin University(Medicine Edition)
2019;45(1):94-99
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the expression of activator of basal transcription 1 (ABT1) protein in gastric cancer tissue and its relationships with the clinical parameters and prognosis of gastric cancer patients, and to clarify the role of ABT1 in the occurrence and development of gastric cancer. Methods: A total of 100 cases of cancer tissue of the gastric cancer patients and 80 pairs of adjacent tissue were selected. The expressions of ABT1 in cancer tissue and adjacent tissue were detected by immunohistochemistry and the proportion of stained cells and the degree of staining in the immunohistochemistry results were analyzed using semi-quantitative analysis. The relationships between the semi-quantitative analysis results and the clinical parameters of gastric cancer patients were statistically analyzed. Kaplan-Meier method was used to analyze the correlation between the ABT1 protein expression level and the survival of gastric cancer patients. Results: ABTl-positive staining was observed in the nucleus and cytoplasm of gastric cancer tissue and adjacent gastric tissue. The expression level of ABT1 in gastric cancer tissue was lower than that in adjacent tissue (P= 0.021). The ABT1 protein expression level in gastric cancer tissue was significantly negatively correlated with the pathological grade (r=-0.224, P = 0. 026). The Kaplan-Meier analysis results of the survival curve showed that the high expression of ABT1 was associated with good prognosis in the gastric cancer patients (HR=1. 483, P<.0. 01). The survival rate of gastric cancer patients with high ABT1 expression was significantly higher than that of the patients with low ABT1 expression (HR = 2.411, P=0. 0272). Conclusion: The expression of ABT1 in gastric cancer tissue is lower, indicating that ABT1 can be used one of the markers of good prognosis of gastric cancer.
