Expressions of Foxp3+ regulatory T cells and myeloid dentritic cells in human colorectal cancer and tumor draining lymph node tissues and their significances
10.13481/j.1671-587x.20190325
- Author:
Dan WANG
1
Author Information
1. Department of Pathology, School of Medical Sciences, Beihua University, Jilin University
- Publication Type:Journal Article
- Keywords:
Colorectal neoplasms;
Myeloid dentritic cells;
Regulatory T cells;
Tumor draining lymph nodes;
Tumor metastasis
- From:
Journal of Jilin University(Medicine Edition)
2019;45(3):621-626
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the expressions of Foxp3 ' Tregs and CDllc mDCs in the colorectal cancer (CRC) tissue and their infiltrations in the tumor draining lymph node (TDLN) tissue, and to explore the clinical significances. Methods: Fifty-two samples of surgical resection of the CRC patients were collected The expressions of Foxp3 + Tregs and CDllc mDCs in the specimens of the CRC patients and TDLN tissue were detected by immunohistochemistry, and the relationship between the expression frequencies of Foxp3 + Tregs and CD11c+ mDCs and the clinicopathological characteristics of the patients were discussed Results: The positive expression frequency of Foxp3 + Tregs in cancer tissue of the CRC patients was higher than that in adjacent normal mucosa tissue (P< 0. 01); The expression frequency of Foxp3 + Tregs in cancer tissue in the patients with positive lymph node metastasis was higher than that in the patients with negative lymph node metastasis (P<0. 01); the expression frequency of Foxp3 + Tregs in the patients in TNM stage III + IV was higher than that in TNM stage I + II (P< 0. 01); the positive expression frequency of Foxp3 Tregs in metastatic TDLN (mTDLN) tissue was higher than that in metastatic free TDLN (mfTDLN) tissue (P<0. 01). The positive expression frequency of CD11c+ mDCs in cancer tissue of the CRC patients was higher than that in adjacent normal mucosa tissue (P<0. 01); the positive expression frequency of CD11c+ mDCs in the patients with positive lymph node metastasis was lower than that in the patients with negative lymph node metastasis (P<0. 01); the positive expression frequency of CDllc1 mDCs in the patients in TNM stage IE + IV was lower than that in the patients in TNM stage I + II (P<0. 01); the positive expression frequencies of CD11c+ mDCs in cancer tissue with different depths invasion were significantly different (P<0. 05); the positive expression frequency of CD11c+ mDCs in mTDLN tissue was lower than that in mfTDLN tissue (P < 0. 01). There were no significant correlations between the expressions of Foxp3 Tregs and CDllc mDCs in the CRC and TDLN tissues (P>0. 05). Conclusion: The occurrence and development of CRC are related to the changes of Foxp3 Tregs and CDllc mDCs expression frequencies in the local microenvironment of cancer tissue. Foxp3+ Tregs and CD11c+ mDCs play a role in inhibiting the cellular immunity in tumor microenvironment.
