Analysis of cyclooxygenase-2 expression in patients with familial adenomatous ployposis
- Author:
Xiao-Dong XU
1
Author Information
1. Department of General Surgery
- Publication Type:Journal Article
- From:
Academic Journal of Second Military Medical University
2006;27(4):370-372
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To analyze the expression of cyclooxygenase-2(COX-2) in patients with familial adenomatous polyposis and to discuss the possible role of COX-2 in adenoma formation and cancerization. Methods: The aden oma specimens were obtained from 10 FAP patients (2001-2003). Different sizes (≤0.5 cm and ≥1 cm) of adenomas and cancerous adenomas were subjected to Envision immunohistochemistry for analysis of COX-2 protein expression. Results: COX-2 was mainly detected in epithelial cells, with some in interstitial cells. When ≤0.5 cm, COX-2 expression in adenomatous epithelial cells was stronger than in normal epithelial cells (P> 0.05); the same was true when ≥1.0 cm, but with statistical significance (P<0.01). The expression of COX-2 in different sizes of adenomas was significantly different (P<0.01), with that in ≥1.0 cm adenomas stronger than that in ≤0.5 cm adenomas. Expression of COX-2 in cancerous adenoma was stronger than that in normal epithelial cells (P<0.01) and epithelial cells of ≥1.0 cm adenomas (P>0.05). Conclusion: COX-2 may be a stimulative factor in the progression of FAP and may participate in adenoma formation and cancerization. Selective inhibition of COX-2 may be an effective strategy for preventing FAP.