Mitochondrial nitric oxide synthase: Biological function
- Author:
Wen-Wu LIU
1
Author Information
1. Department of Diving Medicine
- Publication Type:Journal Article
- From:
Academic Journal of Second Military Medical University
2006;27(6):656-659
- CountryChina
- Language:Chinese
-
Abstract:
Increasing evidences have shown the existance of a mitochondrial nitric oxide synthase (mtNOS), which binds to the matrix face of the mitochondrial inner membrane and produces nitric oxide (NO) through a Ca2+ sensitive pathway. Under physiological condition, the NO catalyzed by mtNOS regulates mitochondrial oxygen consumption and transmembrane potential via reversible competition with cytochrome C oxidase. The reaction of NO with superoxide anion, which was produced by mitochondrial respiratory chain, yields peroxynitrite. Peroxynitrite irreversibly modifies susceptible targets in mitochondria and induces oxidative and/or nitrative stress. In addition, NO has also been implicated in the programmed cell death. This article reviews the current understanding of mtNOS's role in the regulation of mitochondrial functions.
