Low Dose Megestrol Acetate for Maintenance Hemodialysis Patients.
- Author:
Jung Hwan PARK
1
;
Eun LEE
;
Young Il JO
;
Jong Oh SONG
;
Jong Ho LEE
Author Information
1. Department of Nephrology, Konkuk University, School of Medicine, Korea. nephlee@kuh.ac.kr
- Publication Type:Original Article
- Keywords:
Megestrol acetate;
Malnutrition;
Hemodialysis
- MeSH:
Adipose Tissue;
Anorexia;
Appetite;
Cytokines;
Energy Intake;
Humans;
Inflammation;
Interleukin-6;
Male;
Malnutrition;
Megestrol;
Megestrol Acetate;
Nutritional Status;
Pneumonia;
Prevalence;
Quality of Life;
Renal Dialysis;
Serum Albumin;
Thirst
- From:Korean Journal of Nephrology
2009;28(4):302-309
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Maintenance hemodialysis (HD) patients have a high prevalence of malnutrition and inflammation. Megestrol acetate (MA) has been shown to increase appetite in cancer patients but the usual dose of MA (400-800 mg/day) was associated with serious side effects in HD patients. We evaluated the changes in nutritional and inflammatory parameters after low dose of MA treatment in malnourished HD patients METHODS: Inclusion criteria were maintenance HD patients who showed serum albumin <3.5 g/dL or <4.0 g/dL with anorexia. Serum chemical parameters, cytokines, Subjective Global Assessment, dry weight, Kt/V, nPCR, SF36 quality of life, fat free mass (FFM), and body fat mass (BFM) were measured. Patients were instructed to take 5 mL (200 mg) of MA solution once a day. RESULTS: Fourteen patients (seven male, age 52+/-10 years, mean HD duration 48+/-59 months) were included. One patient died of pneumonia. Seven patients dropped out because they refused to take the drug after one to three months of treatment; two of them complained of thirst, three of them ate too much, and two had both. Six patients (four male and two female) have completed six months of study. Serum albumin (3.1+/-0.5 to 3.6+/-0.4 g/dL), TIBC (184.2+/-27.9 to 205.0+/-25.8 microgram/ dL), BFM (11.9+/-5.7 to 16.6+/-7.4 kg), protein intake (57.0+/-32.5 to 68.7+/-39.2 g/day), and energy intake (1,521+/-690 to 1,724+/-879) were increased. Serum CRP and IL-6 decreased without statistical significance. No significant adverse effects were observed in all patients who had completed study. CONCLUSION: Low dose MA can improve the nutritional status, inflammation, and anorexia in maintenance HD patients.
