Phospholipase C signaling pathway and M channel modulation
- Author:
Bo-Yi LIU
1
Author Information
1. Department of Pharmacology
- Publication Type:Journal Article
- From:
Academic Journal of Second Military Medical University
2006;27(10):1138-1141
- CountryChina
- Language:Chinese
-
Abstract:
As an outward, voltage-dependent potassium channel, M type channel is crucial in the regulation of neuronal excitability; it is modulated by a variety of factors in vivo and its dysfunction often results in neuronal system diseases. Great efforts have been made to elucidate the mechanism underlying M channel modulation since its discovery decades ago. It is generally accepted that the Phospholipase C (PLC) signaling pathway plays a significant role in the M channel modulation. This review highlights the relationship between PLC signaling pathway and M channel modulation, as well as some recent progresses in the research of this field.
