Plasma level of matrix metalloproteinase-9 in patients with acute coronary syndrome and its percutaneous coronary intervention
- Author:
Mei-Yan ZHANG
1
Author Information
1. Department of Cardiology
- Publication Type:Journal Article
- From:
Academic Journal of Second Military Medical University
2006;27(10):1105-1109
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To determine the plasma MMP-9 levels in patients with coronary heart disease before and after percutaneous coronary intervention (PCI) and in healthy controls before and after coronary angiography, so as to assess the value of MMP-9 in evaluating the plaque stability in atherosclerosis. Methods: The plasma MMP-9 levels were determined by ELISA in 29 patients with acute myocardial infarction (AMI), 34 patients with unstable angina (UAP), 27 patients with stable angina (SAP), and 28 healthy controls. Meanwhile, their serum hs-CRP levels were measured by particle-enhanced immunonephelometry. Results: The baseline level of MMP-9 was higher in AMI group (171.30 ng/ ml) than those in SAP (52.00 ng/ml, P<0.01) and control (52.75 ng/ml, P<0.01) groups, and was higher in UAP group (143.55 ng/ml) than those in SAP and the control groups (P<0.05). The serum level of hs-CRP was higher in AMI group (5.260 mg/L) than those in UAP (2.040 mg/L, P<0.01), SAP (1.070 mg/L, P<0.01), and the control (0.550 mg/L, P<0.01) groups, and was higher in UAP group than those in the SAP (P<0.05) and the control groups (P<0.01). The levels of MMP-9 were obviously decreased after operation. The change of MMP-9 (ΔMMP-9) in AMI group (135.40 ng/ ml) was more obvious than those in SAP (29.50 ng/ml, P<0.01) and the control (26.50 ng/ml, P<0.01) groups. ΔMMP-9 in UAP (103.05 ng/ml) group was more obvious than those in SAP and the control groups (P<0.05). The plasma levels of MMP-9 were positively correlated with the levels of hs-CRP; neither MMP-9 nor hs-CRP was correlated with Gensini score or the number of diseased arteries. Conclusion: Plasma levels of MMP-9 and hs-CRP can be used for evaluation of plaque stability in coronary atherosclerosis. The post-PCI decrease of plasma MMP-9 level may be related to the improvements of ischemia and inflammation.
