Renal transplantation with or without dialysis in uremic patients: A comparison of clinical outcomes
- Author:
Ming LUO
1
Author Information
1. Organ Transplantation Institute of PLA
- Publication Type:Journal Article
- From:
Academic Journal of Second Military Medical University
2006;27(10):1063-1066
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To compare the clinical outcomes of renal transplantation with or without dialysis in uremic patients, in an effort to assess the feasibility of renal transplantation without dialysis. Methods: The clinical data of 128 uremic patients who received renal transplantation without dialysis during Jan. 2001 and Jul. 2004 (non-dialysis group) were retrospectively analyzed and compared with those of 569 patients who received renal transplantation with dialysis (dialysis group) during the same period. Results: The pre-transplantation hepatitis rate was 4.69% in non-dialysis group and 18.45% in dialysis group (P<0.05). After transplantation, the time for plasma creatinine returning to normal level was (7.26±5.49) d in non-dialysis group and (8.379±4.76) d in the dialysis group (P>0.05). One month after transplantation, the levels of hemoglobin were (96.67±23.54) g/L and (92.17±21.83) g/L in non-dialysis and dialysis group, respectively (P>0.05); and the levels of albumin were (40.28±8.53) g/L and (38.34±7.84) g/L, respectively (P>0.05). The acute rejection rates in non-dialysis group was significantly lower than that of dialysis group(19.53% vs 34.27%, P<0.05); the infectious rate in non-dialysis and dialysis group were 28.13% and 36.38%, respectively (P>0.05). The 1 year survival rates of patient/graft were 98.44% in non-dialysis and 97.72%/95.96% in dialysis group (no significance); the 3 year survival rates of patient/ graft were 96.23% in non-dialysis and 94.4%/88% in dialysis group (no significance). Conclusion: Renal transplantation without dialysis can avoid the dialysis complications and transfusion-induced sensitization, and reduce the risk of hepatitis infection as well as the acute rejection rate; while its patient/graft survival rate is similar to that of dialysis renal transplantation, making it feasible for clinical application.
