Serum expression of monocyte chemoattractant protein-1 and macrophage inhibitory protein-1α in patients with rheumatoid arthritis
- Author:
Jun BAO
1
Author Information
1. Department of Rheumatology
- Publication Type:Journal Article
- From:
Academic Journal of Second Military Medical University
2006;27(11):1226-1228
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the possible role of chemokines monocyte chemoattractant protein-1 (MCP-1) and macrophage inhibitory protein-1 (MIP-1α) in pathogenesis of rheumatoid arthritis (RA). Methods: Enzyme linked immunosorbent assay (ELISA) was used to determine the serum expression of MCP-1 and MIP-1α in 17 patients with early active RA, 18 with advanced active RA, and 15 healthy controls (all aged 18-79 years). Clinical activity indices such as the strength of grip, joint pain index, and joint swelling index were assessed in all subjects; and the serological indices such as erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and rheumatoid factors were also determined. The relationships between serum levels of MCP-1, MIP-1α with the clinical activity indices and serological indices were analyzed. Results: The serum levels of MCP-1 in patients with early and advanced RA were higher than that in the controls (P<0.01), while there was no significant difference between the 2 RA groups. The serum level of MIP-1α in patients with early RA was significant higher than in those with advanced RA and healthy controls (P<0.01), and there was no significant difference between the latter 2 groups. It was found that the serum levels of MCP-1 and MIP-1α in RA patients had no correlations with clinical activity indeices and serological indices. Conclusion: It is confirmed that MCP-1 and MIP-1α participate in the pathogenesis of RA. MIP-1α may play a pivotal role in the pathogenesis of synovitis during early stage of RA. It has not been indicated that MCP-1 and MIP-1α participate in inflammations.
