Quantitative analysis of osteopontin expression in oral squamous cell carcinoma tissues and its clinical significance
- Author:
Lei JIANG
1
Author Information
1. Department of Stomatology
- Publication Type:Journal Article
- From:
Academic Journal of Second Military Medical University
2006;27(11):1222-1225
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To quantitative analyze the expression of osteopontin (OPN) in oral squamous cell carcinoma (OSCC) tissues and its clinical significance. Methods: OPN expression was examined in 59 OSCC (with different clinical and pathological characteristics) and 12 normal oral mucosa (NOM) samples by using immunohistochemical method. The staining results were quantitatively studied by image analyzer. Results: OPN expression was much higher in OSCC sample than that in NOM sample (P<0.05). OPN expression was significantly different in OSCC samples of different clinical stages and with or without cervical lymphatic metastasis: with the expression at stage II (n=16) lower than that at stage III-IV (n=23) but higher than that at stage I (n=20)(both P<0.05), and the expression higher with metastasis (n=20) than that without metastasis (n=39, P<0.05). There was no significant difference between highly differentiated (n=38) and poorly differentiated (n=21) OSCC samples. Conclusion: OPN is over expressed in OSCC tissues and its expression is associated with the clinical stage and the presence of metastasis (with higher expression in late clinical stages and with mestastasis), but not with the differentiation of the tumor.
