Role of angiotensin- II in cell apoptosis
- Author:
Li-Juan YANG
1
Author Information
1. Department of Endocrinology
- Publication Type:Journal Article
- Keywords:
Angiotensin II;
Angiotensin II type 1 receptor blockers;
Angiotensin-converting enzyme inhibitors;
Apoptosis
- From:
Academic Journal of Second Military Medical University
2010;27(12):1368-1371
- CountryChina
- Language:Chinese
-
Abstract:
Angiotensin-II-induced apoptosis was widely involved in the pathogenesis of diabetes mellitus, cardiovascular diseases, etc. The mechanism of angiotensin-II-induced apoptosis is complicated, including the receptor (AT1R and AT2R) level regulation, Fas/FasL pathway, and the regulation by p53 family, Bcl-2 family, Caspase family, Ang-(1-7), etc. Mitochondria damage and oxidative damage play important roles in the apoptosis process. This article reviews the previous researches on angiotensin-II-induced apoptosis.
