Altered expression of E-cadherin/P120 complex in human intrahepatic cholangiocarcinomas: Correlation with clinicopathologic parameters and patients' survival
- Author:
Bo ZHAI
1
Author Information
1. International Cooperation Laboratory on Signal Transduction
- Publication Type:Journal Article
- Keywords:
Bile duct neoplasms;
Bile ducts;
E-cadherin;
Intrahepatic;
P120;
Prognosis
- From:
Academic Journal of Second Military Medical University
2010;27(12):1324-1327
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the expression of P120 in intrahepatic cholangiocarcinomas (ICCs) and its correlation with the clinicopathologic parameters and patients' survival. Methods: An immunohistochemical study was performed using Dako EnVision Kit to detect the expression of E-cadherin and P120-catenin in 42 ICC specimens. Results: The expression of E-cadherin and P120 was reduced in 27 (64.3%) specimens and 31 (73.8%) specimens, respectively. The expression of E-cadherin and P120 was significantly correlated with the tumor histological grade (P=0.009 and P=0.003, respectively), pTNM stage (P=0.035 and P=0.004, respectively), intrahepatic metastasis (P=0.007 and P=0.041, respectively), and patients' survival periods (P=0.024 and P=0.004, respectively). In addition, the expression of P120 accorded with that of E-cadherin (P<0.001). We also found that P120 expression and the tumor size were the independent prognostic factors for ICC patients by a Cox regression model. Conclusion: Down-regulation of E-cadherin and P120 expression occurs frequently in ICC patients, which might be associated with the progression and development of ICC. Both of them may be valuable biologic markers for predicting tumor invasion, metastasis and patients' survival, but only P120 was an independent prognostic factor for patients' survival.
