Relationship between HLA-DRB alleles and primary biliary cirrhosis in patients living in northern China
- Author:
Jun ZHAO
1
Author Information
1. Third Department of Infectious Diseases
- Publication Type:Journal Article
- Keywords:
Alleles;
Biliary;
HLA antigens;
Liver cirrhosis;
Microarray analysis
- From:
Academic Journal of Second Military Medical University
2010;27(12):1286-1289
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the relationship between HLA-DRB alleles and primary biliary cirrhosis (PBC) in patients living in northern China. Methods: The HLA-DR genes of 40 PBC patients and 67 healthy controls were genotyped by using DNA microarray technique. The subjects in the 2 groups were matchable in their ages and gender ratios. Results: The frequency of HLA-DR7 was 50% in PBC patients, which was significantly higher than that of healthy controls (10.4%) (X2= 20.77, P=0.000, RR=8.57) and those reported in another 2 literatures (23.2%, [N=342, P=0.000] and 29%, [N=255, P - 0.008]). The frequency of HLA-DR8 was 22.5% in PBC patients, which was significantly higher than that of healthy controls (7.5%, [X2=4.980, P=0.026, RR=3.60]) and those reported in the other 2 literatures (11.2%, [N=342, P= 0.038] and 10.2%, [N=255, P=0.025]). Conclusion: It is suggested that the morbidity of PBC in northern Chinese citizens is associated with HLA-DR7 and DR8. DR7 has not been reported in literatures outside China.
