Synthesis of 9-fluorenylmethoxycarbonyl amino acid tert-butyl ester
- Author:
You-Jun ZHOU
1
Author Information
1. Department of Medical Chemistry
- Publication Type:Journal Article
- Keywords:
9-Fluorenylmethoxycarbonyl;
Amino acid;
Synthesis;
Tert-butyl ester
- From:
Academic Journal of Second Military Medical University
2010;28(1):101-102
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To search for a new method for synthesis of 9 fluorenylmethoxycarbonyl amino acid tert-butyl ester. Methods: Glycine, L-Proline, and L-Phenylanaline were separately allowed to react with 9-fluorenylnmthylchloroformate to obtain the corresponding 9-fluorenylmethoxycarbonyl amino acids. With 4-(dimethylamine) pyridine (DMAP) used as catalyst, the 9-fluorenylmethoxycarbonyl amino acids were allowed to react with Tert butyl dicarbonate for the corresponding 9-fluorenylmethoxycarbonyl amino acid tert-butyl esters. Results: Three 9-fluorenylmethoxycarbonyI amino acid tert-butyl esters were successfully synthesized by this method and their structures were confirmed by 1 H NMR. Conclusion: Ours is a simple method with mild condition and high yielding rate for synthesis of 9-fluorenylmethoxycarbonyl amino acid tert-butyl esters.
