A Study on the MIC of Antibiotics for Propionibacterium acnes in Patients with Acne.
- Author:
Yeon Soon LIM
;
Ki Bum MYUNG
;
Nak Eun CHUNG
;
Wha Soon CHUNG
- Publication Type:Original Article
- Keywords:
Acne;
Propinibacterium acnes;
MIC
- MeSH:
Acne Vulgaris*;
Anti-Bacterial Agents*;
Asian Continental Ancestry Group;
Cefoxitin;
Chloramphenicol;
Clindamycin;
Erythromycin;
Humans;
Propionibacterium acnes*;
Propionibacterium*;
Tetracycline
- From:Korean Journal of Dermatology
1995;33(3):437-444
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Propioriacterium acnes plays an importantol in the development of inflammatory acne, and inflarnmatory lesions are improved by oralnc topical antibiotics. But as Pacnes frequently develop resistance to antibiotics in patients neing long term systemic antibiotic therapy, the theravuti effects diminish, and eventually thay fails. OBJECTIVE: The purpose of this study is to evaluate theerral susceptability of P. acnes to antibiotics and the difference in the MIC depending on the of oral and/or topical antibiotics, therapeutic effects and disease duration in patients with acie ulgaris. METHODS: We used twenty six strains of P. acnes which were obtained from patients with acne and performcd suseptibility testing for antibiotics usir the E test procedure. RESULTS: 1. The growth of P. acnes was completely inhibited by e ythromycin and chloramphenicol at concentrations of 0.023ug/ml and 0.064ug/ml, respectively cefoxitin at 0.094ug/ml, and by tetracycline and clindarnycin at 0.190 ug/ml. 2. P. acnes was mot susceptible to erythromycin, and olwed by chloramphenicol, cefoxitin, tetracycline, clindamycin in order of decreasing susceptibilit . 3. There were no significant differences in the MIC in reat in to previous antibiotic treatment. 4. For tetracycline, The MIC was significantly lower(p<0.01) in patients who improved after treatment. 5, For tetracycline and chloramphenicol, the MIC was grficantly lower(p<0.05) in patients with less than 2 years disease duration. CONCLUSION: The susptibility of antibiotics for P. acneias highest in erythromycin. There were no significant differences in the MIC in relation to prvious antibiotic treatment, and for some antibiotics the suseptibility was low in patients who dill not show clinical improvement or who had long disease duration.
