Expression of CD105 in oxygen-induced retinal neovascularization models in mice
- Author:
Juan LI
1
Author Information
1. Department of Ophthalmology
- Publication Type:Journal Article
- Keywords:
CD105;
Retinal diseases;
Retinal neovascularization
- From:
Academic Journal of Second Military Medical University
2010;28(2):166-169
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the expression of CD105 in oxygen-induced retinopathy (OIR) in C57BL/6J mice. Methods: Forty 7-day old C57BL/6J mice were evenly randomized into normal control group and hyperbaric oxygen group. The OIR model was induced with hyperbaric oxygen; the retinal neovascularization was observed by H-E staining and the expression of CD105 in OIR was observed by immunohistochernistry staining. Results: H-E staining indicated that the retinal neovascularization model was successfully estabished. CD105 was strongly expressed in the hyperbaric oxygen group, with the integral photodensity of angiogenesis being 9 985.63 ± 1 016.28 per mouse and the positive staining area being (14 246.61 ± 6 052.29) μm2 per mouse; CD105 was weakly expressed in the control group with the integral photodensity of angiogenesis being 1 625.36 ± 638.44 per mouse and the positive staining area being (3 619.31 ± 1 760.03) μm2 per mouse; the differences between the 2 groups were statistically significant (P < 0.01). Conclusion: CD105 may play a role in the retinal neovascularization; detection of CD105 might be valuable in evaluating retinal neovascularization and the subsequent treatment.
