Chemical constituents in roots of Angelica dahurica var. formosana
- Author:
Jia LU
1
Author Information
1. Department of Natural Medicinal Chemistry
- Publication Type:Journal Article
- Keywords:
Alkaloid;
Angelica dahurica;
Chemical constituents;
Linear 6, 7-furanocourmarins
- From:
Academic Journal of Second Military Medical University
2010;28(3):294-298
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the chemical constituents in the roots of Angelica dahurica var. formosana. Methods: The dried rhizomes of Angelica dahurica var. formosana were chopped and extracted with 80% EtOH for 3 times under reflux. The EtOH extract was isolated by chromatography on silica gel using a gradient solvent system (PE: EtOAc & CHCl3: MeOH) and Sephadex LH-20. The structures of the contents were elucidated by nuclear magnetic resonance and MS spectral analysis. Results: Seventeen compounds were identified, namely, isoimperatorin (1), imperatorin (2), bergapten (3), alloimperatorin(4), xanthotoxol (5), cnidilin (6), byakangelicin (7), bergaptol (8), byakangelicol (9), pabulenol (10), oxypeucedanin hydrate(11), desmodimine (12), palmitic acid (13), stiamasterol (14), β-sitosterol (15), β-daucosterin (16), and sucrose(17). Conclusion: Compounds 8 and 12 have been isolated from Angelica dahurica var. formosana for the first time. Compound 12 has been firstly isolated from Umbelifera plants. All the courmarin compounds belong to linear 6, 7-furanocourmarins.
