Effect of transdermal penetration enhancers on permeation ability of indomethacin and salbutamol
- Author:
Fei WANG
1
Author Information
1. Department of Pharmaceutics
- Publication Type:Journal Article
- Keywords:
Albuterol;
Indomethacin;
Penetration enhancer;
Skin absorption
- From:
Academic Journal of Second Military Medical University
2010;28(4):421-424
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the effect of different transdermal penetration enhancers on the skin permeation ability of indomethacin and salbutamol in vitro. Methods: Valia-Chien diffusion cell was adopted as the apparatus for in vitro skin permeation test. Excised SD-rat abdomen skin was pretreated with penetration enhancers including Azone, Propylene glycol, N-methylpyrrolidone, oleic acid, peppermint oil, and a combination of Azone and Propylene glycol. A UV method was established to determine the contents of indomethacin and salbutamol in receiver diffusion cells. Results: Compared with blank control group, all the enhancers showed significant enhancement effect on the permeability of indomethacin and salbutamol except for propylene glycol (P < 0.01). Azone combined with propylene glycol showed the greatest ability to enhance the flux of indomethacin(125.91 μg · cm-2 · h-1) and salbutamol(155.94 μg · cm-2 · h-1). Conclusion: Azone combined with Propylene glycol, Azone, N-methylpyrrolidone, Oleic acid, and Peppermint oil can be used as penetration enhancers in the transdermal preparation of compound indomethacin.
