Expression of suppressor of cytokine signaling 2 in breast carcinoma by tissue microarray
- Author:
Yu-Zhao ZHU
1
Author Information
1. Department of Pathology
- Publication Type:Journal Article
- Keywords:
Breast neoplasms;
Microarray analysis;
Supressors of cytokine signaling
- From:
Academic Journal of Second Military Medical University
2010;28(4):393-395
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the expression of suppressor of cytokine signaling 2 (SOCS2) in breast carcinoma tissues and to discuss its relationship with clinical pathological data of breast carcinoma patients. Methods: The tissue microarray for 171 cases of breast carcinoma specimens, 18 adjacent tissues and 20 breast benign lesions were established. Then the expression of SOCS2, ER, PR, cerbB2, p53 and Ki-67 was detected by tissue microarray technique and S-P immunohistochemistry. Results: Positive rates of the SOCS2 protein in the breast carcinoma specimens, adjacent tissues and breast benign lesion were 57.89% (99/ 171), 94.44% (17/18), and 75% (15/20), respectively. The expression of SOCS2 was significantly different in breast carcinoma tissues of different TNM classification, different histological grades, and with or without Ki-67 expression and lymphatic metastasis (P<0.05). Conclusion: The lower expression of SOCS2 might contribute to oncogenesis of breast carcinoma and poor prognosis.
