Expression of chemokines and chemokine receptors in organ-graft rejection: Recent progress
- Author:
Liang XIAO
1
Author Information
1. Department of Liver Transplantation
- Publication Type:Journal Article
- Keywords:
Chemokine;
Chemotactic factors;
Graft rejection;
Organ transplantation;
Receptors
- From:
Academic Journal of Second Military Medical University
2010;28(6):659-661
- CountryChina
- Language:Chinese
-
Abstract:
Acute and chronic graft rejection are the major factors leading to graft non-function. There is an active expression of chemokines early after transplantation. They recruit T cells and antigen presenting cells selectively to the graft, leading to inflammatory reaction and finally to graft non-function. Accordingly, monitoring the expression status of chemokines and their receptors regularly may help to the diagnose rejection. To determine one or more chemokines or their receptors as the new targets for anti-rejection therapy will be of great clinical significance. This review focuses on the research progression in the above areas.
