Radiofrequency ablation for larger hepatocellular carcinomas
- Author:
Bo ZHAI
1
Author Information
1. Department of Ultrasonic Intervention
- Publication Type:Journal Article
- Keywords:
Carcinoma;
Catheter ablation;
Hepatocellular;
Liver neoplasms
- From:
Academic Journal of Second Military Medical University
2010;28(6):651-655
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the treatment outcome of percutaneous image-guided radiofrequency ablation (RFA) for larger hepatocellular carcinomas (with the maximal diameter longer than 4 cm) and to summarize our experience. Methods: From December, 1999 to March, 2007, 441 patients with larger hepatocellular carcinomas, who had missed the best time for surgery, received RFA treatment in our department. The maximal diameter of the tumor was 4-8. 2 cm, with a mean of (4.6 ± 0.63) cm. The patients were followed up and the necrosis of the tumor, complication, local recurrence and survival of patients were observed. Results: The complete necrosis rate of tumors was 72.9%. The rate of RFA-associated complication was 20.9% and the rate of severe complication was 9.5%. Seven patients died of RFA. Valid follow-up data of 359 patients were obtained, including 379 tumors with diameter longer than 4 cm. A total of 302 tumors were completely necrotic and 130 of them had recurrence, with a recurrence rate of 43.0%. For patients with a tumor diameter of 4-5 cm, the 1-year, 3-year, and 5-year survival rates were 78.2%, 48.1%s, and 17.6%, respectively, with a median survival period of 27 months; for patients with a tumor diameter of 5-6 cm, the rates were 66.3%, 36.4% and 9.7%, respectively, with a median survival period of 18 months; for patients with a tumor diameter longer than 6 cm, the rates were 53.6%, 28.1%, and 0, respectively, with a median survival period of 11 months. Conclusion: RFA is an effective treatment for patients with larger HCC who are not suitable for surgery, but the patients should be selected according to the indications.
