Expression of MMP-13 in breast cancer and its relationship with prognosis of breast cancer
- Author:
Chun-Geng LI
1
Author Information
1. Department of Anus-Intestine
- Publication Type:Journal Article
- Keywords:
Breast neoplasms;
Diagnosis;
Matrix metalloproteinases-13;
Microarray;
Prognosis
- From:
Academic Journal of Second Military Medical University
2010;28(9):960-963
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the expression of MMP-13 in breast cancer tissues and its relationship with clinical prognosis of patients. Methods: Tissue microarray and immunohistochemical SP method were used to detect the expression of MMP-13 in 183 specimens of breast cancer. The association between the expression of MMP-13 and the clinicopathologic parameters of patients was analyzed; the association between MMP-13 and the prognosis of breast cancer was also discussed based on 10 years' follow-up data. Results: The positive rate of MMP-13 in the breast cancer tissue (54.1%) was significantly higher than that in the benign breast tissues (13.3%, P<0.01). MMP-13 expression was significantly correlated with the clinical TNM stage, histological grade and lymph node metastasis status of the malignancy (P<0.01), but was not correlated with patients' age, tumor size, pathological type, period status, and the status of estrogen receptor and progesterone receptors. The 10-year survival rate of patients with over-expression of MMP-13 was lower than patients with low MMP-13 expression (P<0.01). Conclusion: MMP-13 expression is upregulated in breast cancer tissues, which is an indicator of poor prognosis of patients.
