Influence of sulfonylureas on cardiovascular system: Progress in basic research and clinical research
- Author:
Guo-Liang JIANG
1
Author Information
1. Department of Endocrinology
- Publication Type:Journal Article
- Keywords:
ATP-sensitive K+ channels;
Cardiovascular disease;
Peroxisome proliferator-activated receptors;
Sulfonylureas
- From:
Academic Journal of Second Military Medical University
2010;28(9):1008-1010
- CountryChina
- Language:Chinese
-
Abstract:
Previous studies have showed that sulfonylureas possess a bidirectional effect on cardiovascular system: they can raise the coronary artery tone, aggravate ischemic injury to the cardiovascular tissues, and accelerate cardiac hypertrophy through closing cardiovascular ATP-sensitive K+ channels; meanwhile, they can also regulate glucolipid metabolism, modulate inflammatory reaction and inhibit atherosclerosis through activating peroxisome proliferator-activated receptors. Clinical-epidemiological study showed different opinions on whether sulfonylureas can increase the mortality of patients with cardiovascular diseases.
