Diagnosis accuracy of mammography, magnetic resonance image, and radionuclide imaging for breast cancer: A meta-analysis
- Author:
Jing ZHANG
1
Author Information
1. Department of Radiology
- Publication Type:Journal Article
- Keywords:
Breast neoplasms;
Magnetic resonance image;
Mammography;
Meta analysis;
Radionuclide imaging
- From:
Academic Journal of Second Military Medical University
2010;28(10):1098-1103
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To compare the performance of mammography, magnetic resonance image and positron emission tomography/single photon emission computed tomography (PET/SPECT) in the diagnosis of breast cancer by Meta analysis. Methods. Based on the assessment standard of evidence-based diagnostic experiment, we searched PubMed, OVID, and Medline database (1986-2006) for the articles on the diagnosis of breast cancer with MG, MRI, PET and/ or SPECT. The data and parameters of the 3 diagnostic methods were subjected to Meta analysis. Using software Excel 2003, SPSS13.0 and RevMan 4.2, we calculated the summary sensitivity and specificity, the pooled odds ratio (OR) and likelihood (LR). Summary receiver operating characteristic curve (SROC) was drawn to evaluate accuracy of the 3 methods. Results: We obtained 30 articles, which included 41 data sets: 14 on MG (2 941 lesions), 10 on MRI (1 428 lesions), and 17 on PET/SPECT (2 247 lesions). The pooled estimates for sensitivity of MG, MRI and PET/SPECT were 82%(95%CI:76%-86%), 86%(95%CI:83%-88%), and 87%(95%CI:83%-90%), respectively; for specificity were 69%(95%CI:62%-75%), 65%(95%CI:62%-69%), and 82% (95%CI:76%-86%), respectively. Their weighted AUC (area under curve) were 0.84, 0.89 and 0.90, respectively;Q* values were 0.77, 0.81 and 0.88, respectively. The sensitivities of the 3 methods were not significantly different. The specificity of PET/SPECT was higher than those of MG and MRI (P<0.05). The overall diagnostic efficacies of PET/SPECT and MRI were better than that of MG. Conclusion: MG remains to be a satisfactory method for initial diagnosis of breast cancer; MRI examination should first be considered for younger patients. PET/SPECT should be used when a diagnosis of breast cancer can not be confirmed.