Analysis of clinical laboratory parameters of 828 patients with hepatocellular carcinoma
- Author:
Yun-Peng ZHAO
1
Author Information
1. Department of Laboratory Medicine
- Publication Type:Journal Article
- Keywords:
Carcinoma, hepatocellular;
Diagnosis;
Tumor markers, biological
- From:
Academic Journal of Second Military Medical University
2010;28(12):1296-1301
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To retrospectively analyze the routine clinical laboratory parameters for hepatocellular carcinoma, in an attempt to search for parameters for diagnosis of HCC. Methods: The pre-operation clinical laboratory data, such as tumor makers, and serological biochemical indices, hepatitis B virus (HBV) infection markers, and HBV DNA titers, were collected from 828 patients who were pathologically diagnosed as having HCC; then the correlation between these data with tumor size and the pathological grades of HCC was analyzed. Results: It was found that 97.9% of the 828 patients were infected with HBV and 70.9% of them were accompanied by liver fibrosis. We also found that the tumor size was correlated with albumin (Alb), globulin (GLB), A/ G, spartate aminotransferase (AST), ratio of aspartate to alanine aminotransferase (AST/ALT), gamma-glutamyl transferase (GGT), alkaline phosphatase (ALP), alpha-L-fucosidase (AFU), alpha fetoprotein (AFP) and tumor grades; meanwhile, the pathological grades of tumor was correlated to PALB, GGT and tumor size(all P<0.05). Conclusion: The progress of HCC is correlated with several clinical laboratory biochemistry indices and virus indices. The combined application of these indices is worth studying for auxiliary diagnosis of HCC.
