Modulation of potassium channels by receptor tyrosine kinases: Recent progress
- Author:
Zhan-Feng JIA
1
Author Information
1. Department of Pharmacology, Hebei Medical University
- Publication Type:Journal Article
- Keywords:
Modulation;
Potassium channels;
Receptor tyrosine kinases;
Signal transduction
- From:
Academic Journal of Second Military Medical University
2010;29(2):206-210
- CountryChina
- Language:Chinese
-
Abstract:
Receptor tyrosine kinase (RTK), a membrane receptor superfamily with intrinsic protein tyrosine kinase activity, has many members and complicated signal transduction pathways. Activation of RTKs can trigger a series of signal transduction pathways and play essential roles in modulating cell growth, proliferation, differentiation and metabolism through influencing gene transcription and expression. Activation of RTK can also rapidly modulate some cellular functions including the modulation of ion channels. Potassium channels play a critical role in stabilization of membrane potential and regulation of cellular excitability. This review highlights the rapid modulation of potassium channels by RTKs and reviews the recent progress in related research.
