High CyPA expression in non-small cell lung cancer and its relationship with clinical pathological characteristics
10.3724/SP.J.1008.2008.00146
- Author:
Yan-Ming FENG
1
Author Information
1. Department of Occupational Medicine
- Publication Type:Journal Article
- Keywords:
Cyclophilin A;
Immunohistochemistry;
Lung neoplasms;
Microarray;
Non-small cell lung carcinoma
- From:
Academic Journal of Second Military Medical University
2010;29(2):146-149
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the expression and distribution of CyPA in non-small cell lung cancer (NSCLC) and to evaluate its clinical significance in the development and progression of NSCLC. Methods: The expression of CyPA was examined in 45 NSCLC tissues, 22 paired tumor-adjacent tissues and 33 normal pulmonary tissues using tissue microarray immunohistochemistry method. The relationship between CyPA expression in NSCLC and clinic pathological characteristics of NSCLC was analyzed. Results: Expression of CyPA in NSCLC tissues and paired tumor-adjacent tissues was significantly higher than that in the normal pulmonary tissues (P<0.05). No significant correlation was found between the expression of CyPA and differentiation and histological types of NSCLC. Conclusion: CyPA is overexpressed in NSCLC tissues, suggesting that CyPA might serve as a biomarker for the development and progression of NSCLC, whose specific role remains to be further studied.
