Asymmetric synthesis of L-Norvaline
10.3724/SP.J.1008.2008.00324
- Author:
Jun ZHANG
1
Author Information
1. Department of Organic Chemistry
- Publication Type:Journal Article
- Keywords:
Asymmetry;
L-norvaline;
Synthesis
- From:
Academic Journal of Second Military Medical University
2010;29(3):324-325
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To synthesize optic pure L-norvaline. Methods: L-Norvaline was synthesized using n-butyraldehyde and potassium cyanide as starting material and (S)-(-)-α-methylbenzylamine as a chiral auxiliary agent by a selective Strecker reaction. Nearly optical pure α-amino nitrile was obtained by recrystallization; L-Norvaline was then obtained by hydrolysis and catalyzed debenzylation of α-amino nitrile. Results: The optimized reaction solvent system was chosen and high optical pure L-Norvaline was obtained by twice recrystallization procedure. Conclusion: Our method has less steps and is more selective than conventional methods and has a higher yield (47.4%).
