Relationship of TSP-1 expression with metastasis and prognosis of human pancreatic cancer
10.3724/SP.J.1008.2008.00271
- Author:
Hai LIN
1
Author Information
1. Department of General Surgery
- Publication Type:Journal Article
- Keywords:
Neoplasm metastasis;
Pancreatic neoplasms;
Prognosis;
Thrombospondin 1
- From:
Academic Journal of Second Military Medical University
2010;29(3):271-275
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the relationship of TSP-1 expression with the metastasis and prognosis of human pancreatic cancer. Methods: The expression and distribution of TSP-1 were investigated in 74 pancreatic cancer tissues and 16 other pancreatic tissues (6 normal pancreatic tissues, 4 chronic pancreatitis tissues and 6 normal pancreatic tissues adjacent to the pancreatic cancer tissues) using immunohistochemical method. The data were analyzed by using SPSS 11.0 software and the value of TSP-1 expression in predicting the metastasis and prognosis of pancreatic cancer was investigated. Results: The expression of TSP-1 in the pancreatic cancer tissues was significantly higher than that in the normal pancreatic and chronic pancreatitis tissues (P<0.05). Significant differences were also found between tumors of different stages, different sizes, with or without lymphatic metastasis, and with or without neural infiltration (P<0.01 or P<0.05). Logistic regression analysis showed that TSP-1 expression was correlated with the stages and neural infiltration of the tumor. Univariate analysis using the Kaplan-Meier method and log-rank test revealed a relationship of TSP-1 expression with lymphatic metastasis, neural infiltration, tumor stage and patient survival rate. Multivariate analysis using the Cox proportional hazard model demonstrated that the neural filtration, lymphatic metastasis were the independent factors of patients' prognosis and survival; TSP-1 expression was not independent prognostic parameter. Conclusion: Expression and distribution of TSP-1 may serve as indicator for metastasis of pancreatic cancer and is also helpful in predicting the prognosis of pancreatic cancer.
