Consecutive Reversible Changes of Peripheral Nerve Conduction in Tetrodotoxification.
- Author:
Jong Ho PARK
;
Sung Min KIM
;
Jae Cheon BAE
;
Ki Han KWON
;
Byung Chul LEE
;
Harry NA
- Publication Type:Original Article
- Keywords:
Tetrodotoxin;
Nerve conduction study
- MeSH:
Action Potentials;
Eating;
Humans;
Muscles;
Nervous System Diseases;
Neural Conduction;
Neurologic Manifestations;
Peripheral Nerves*;
Tetraodontiformes;
Tetrodotoxin;
Voltage-Gated Sodium Channels
- From:Journal of the Korean Geriatrics Society
1999;3(2):102-107
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Tetrodotoxin (TTX) cause neurologic dysfunction by blocking the voltage-gated sodium channels located in all of the peripheral nerves and muscles. We experienced two patients presenting with generalized motor weakness after ingestion of pufferfish. The nerve conduction study showed diffuse slowing of motor and sensory nerve conduction velocity, prolonged motor terminal latency and decreased sensory nerve action potentials without temporal dispersion or conduction block. Abnormal findings of nerve conduction study improved rapidly without any deterioration. Clinical symptoms and signs ameliorated in accordance with findings of nerve conduction study without any neurologic sequelae. These imply that tetrodotoxication is reversible and functional neurologic disorder. We suggest that nerve conduction studies can be available in serial monitoring of tetrodotoxication as an objective means.
