Ramipril in combination with irbesartan for treatment of chronic heart failure in patients with rheumatic heart disease
10.3724/SP.J.1008.2008.00675
- Author:
Ping DING
1
Author Information
1. Department of Cardiothoracic Surgery
- Publication Type:Journal Article
- Keywords:
Chronic heart failure;
Irbesartan;
Ramipril;
Rheumatic heart disease
- From:
Academic Journal of Second Military Medical University
2010;29(6):675-678
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the effectiveness of irbesartan in combination with ramipril for treatment of chronic heart failure in patients with rheumatic heart disease (RHD). Methods: A total of 120 RHD patients with chronic heart failure were randomized into treatment group (n=60) and control group (n=60) after valve replacement. All patients received regular ramipril treatment (5 mg/d); treatment group were also given irbesartan (150 mg/d). The patients were followed up for 6 months. The indices of observation included cardiac function (NYHA Class), 6-Minute Hall-Walk distance, and echocardiographic parameters. Results: Six months later the cardiac function in the treatment group was obviously improved compared with the control group; the patients in the treatment group had significant increase in 6-Minute Hall-Walk distance and improvement in echocardiographic parameters (left ventricle end systolic diameters, end-diastolic diameter, ejection fraction, fractional shortening, P<0.05). Conclusion: Irbesartan in combination with ramipril can obviously improve the cardiac function and reverse ventricle remodeling in RDH patients with chronic heart failure.
